Three novel methods for determining motor threshold with transcranial magnetic stimulation outperform conventional procedures.

ABSTRACT: Objective. Thresholding of neural responses is central to many applications of transcranial magnetic stimulation (TMS), but the stochastic aspect of neuronal activity and motor evoked potentials (MEPs) challenges thresholding techniques. We analyzed existing methods for obtaining TMS motor threshold and their variations, introduced new methods from other fields, and compared their accuracy and speed.Approach. In addition to existing relative-frequency methods, such as the five-out-of-ten method, we examined adaptive methods based on a probabilistic motor threshold model using maximum-likelihood (ML) or maximuma-posteriori(MAP) estimation. To improve the performance of these adaptive estimation methods, we explored variations in the estimation procedure and inclusion of

SUBMITTER: Wang B 

PROVIDER: S-EPMC10516469 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature