Cardiorespiratory fitness is associated with hippocampal resting state connectivity in women newly diagnosed with breast cancer.

ABSTRACT:

Background

Breast cancer and its treatment are associated with aberrant patterns of resting state functional connectivity (rsFC) between the hippocampus and several areas of the brain, which may account for poorer cognitive outcomes in patients. Higher cardiorespiratory fitness (CRF) has been associated with enhanced rsFC and cognitive performance; however, these associations have not been well studied in breast cancer. We examined the relationship between CRF, rsFC of the hippocampus, and cognitive performance among women newly diagnosed with breast cancer.

Methods

Thirty-four postmenopausal women newly diagnosed with Stage 0-IIIa breast cancer (M_age = 63.59 ± 5.73) were enrolled in a 6-month randomized controlled trial of aerobic exercise vs. usual care.

SUBMITTER: Lesnovskaya A 

PROVIDER: S-EPMC10516482 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature