Temporal landscape of mitochondrial proteostasis governed by the UPR^mt.

ABSTRACT: Breakdown of mitochondrial proteostasis activates quality control pathways including the mitochondrial unfolded protein response (UPR^mt) and PINK1/Parkin mitophagy. However, beyond the up-regulation of chaperones and proteases, we have a limited understanding of how the UPR^mt remodels and restores damaged mitochondrial proteomes. Here, we have developed a functional proteomics framework, termed MitoPQ (Mitochondrial Proteostasis Quantification), to dissect the UPR^mt's role in maintaining proteostasis during stress. We find essential roles for the UPR^mt in both protecting and repairing proteostasis, with oxidative phosphorylation metabolism being a central target of the UPR^mt. Transcriptome analyses together with MitoPQ reveal that UPR<

SUBMITTER: Uoselis L 

PROVIDER: S-EPMC10516501 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature