Histological findings associated with treatment response in cutaneous leishmaniasis: a clinicopathological correlation study.

ABSTRACT:

Background

Treatment responses to cutaneous leishmaniasis (CL) observed in Sri Lanka show variability, ranging from quick healing to delayed or failed responses to routine medication. The determinants of these differences in treatment response are not well defined. This study aimed to identify predictive features of treatment response and outcome in localized CL caused by Leishmania donovani, focusing on both clinical and histopathological findings in the patients.

Methods

Tissue sections (n = 103) derived from 3 mm punch biopsies of parasitologically confirmed patients were assessed. Patients were followed up weekly until complete healing of skin lesions and were reviewed at the end of 6 months and 1 year.

Results

Healing required 7-21 weekly doses of intralesional s

SUBMITTER: Riyal H 

PROVIDER: S-EPMC10516507 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature