In vitro and in vivo evaluation of dual Clofazimine and Verapamil loaded PLGA nanoparticles.

ABSTRACT: Combination therapy may counter the risk caused by efflux pumps mediated resistance developed by mycobacteria with a concomitant increase of the bactericidal effect of anti-TB drugs. In the present study, combination of two drugs in a nanoformulation was prepared. Clofazimine targets type 2 NADH dehydrogenase of the electron transport chain, and Verapamil inhibits various mycobacterial efflux pumps. The nanotechnology approach was adopted to overcome limitations associated with administration of free form of drugs by using poly (D, L-lactic-co-glycolic acid) as a polymer. Nanoparticles were prepared by oil/water single emulsion solvent evaporation procedure and characterized by various techniques. The results thus highlighted that developed nanoparticles were spherical with nano range size

SUBMITTER: Kaur B 

PROVIDER: S-EPMC10516816 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature