TRIP13 overexpression in hepatocellular carcinoma: implications for poor prognosis and immune cell infiltration.

ABSTRACT:

Purpose

The overexpression of TRIP13 has been observed in many types of cancer and has been identified as an oncogene. However, its role in hepatocellular carcinoma (HCC) has not been extensively studied. This study aimed to investigate the expression of TRIP13 in HCC and its impact on immune cell infiltration and prognosis.

Methods

We analyzed TCGA and GSE62232 datasets to assess TRIP13 expression in HCC. Kaplan-Meier and subgroup analysis were performed to examine the correlation between TRIP13 expression and HCC. Univariate and Cox regression analysis were conducted to determine the predictive value of TRIP13 in assessing patient outcomes. A nomogram was developed using TRIP13 mRNA expression to predict HCC prognosis. TRIP13 expression was validated using immunohistochemi

SUBMITTER: Xue J 

PROVIDER: S-EPMC10516817 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature