Ontology highlight
ABSTRACT:
SUBMITTER: Shin SC
PROVIDER: S-EPMC10516900 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Shin Sang Chul SC Park Jinyoung J Kim Kyung Hee KH Yoon Jung Min JM Cho Jinhong J Ha Byung Hak BH Oh Yeonji Y Choo Hyunah H Song Eun Joo EJ Kim Eunice EunKyeong EE
Communications biology 20230922 1
USP47 is widely involved in tumor development, metastasis, and other processes while performing a more regulatory role in inflammatory responses, myocardial infarction, and neuronal development. In this study, we investigate the functional and biochemical properties of USP47, whereby depleting USP47 inhibited cancer cell growth in a p53-dependent manner-a phenomenon that enhances during the simultaneous knockdown of USP7. Full-length USP47 shows higher deubiquitinase activity than the catalytic ...[more]