T cell exhaustion is associated with cognitive status and amyloid accumulation in Alzheimer's disease.

ABSTRACT: Studies over the last 100 years have suggested a link between inflammation, infectious disease, and Alzheimer's Disease (AD). Understanding how the immune system changes during the development of AD may facilitate new treatments. Here, we studied an aging cohort who had been assessed for AD pathology with amyloid positron emission tomography and cognitive testing, and conducted high dimensional flow cytometry on peripheral blood mononuclear and cerebrospinal fluid cells. Participants were assigned a classification of being amyloid negative cognitively normal, amyloid positive cognitively normal (APCN), or amyloid positive mild cognitive impairment (APMCI), an early stage of AD. We observed major alterations in the peripheral innate immune system including increased myeloid and plasmacytoid

SUBMITTER: Grayson JM 

PROVIDER: S-EPMC10516910 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature