Localization Pattern of Dispatched Homolog 2 (DISP2) in the Central and Enteric Nervous System.

ABSTRACT: Dispatched homolog (DISP) proteins have been implicated in the regulation of hedgehog signaling during embryologic development. Although DISP2 has recently been associated with neuronal development and control of cognitive functions, its localization pattern in the mammalian central and peripheral nervous system has not yet been investigated. In this study, the Disp2 expression profile was assessed in human tissues from publicly available transcriptomic datasets. The DISP2 localization pattern was further characterized in the human and rat central nervous system (CNS), as well as within the colonic enteric nervous system (ENS) using dual-label immunohistochemistry. Colocalization of DISP2 with neuronal and glial markers was additionally analyzed in murine primary ENS culture. At transcript

SUBMITTER: Heimke M 

PROVIDER: S-EPMC10517031 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature