Identification of Immune-Linked Hub Genes and Diagnostic Model Construction in Schizophrenia.

ABSTRACT: Schizophrenia (SCZ) is a prevalent, severe, and persistent mental disorder with an unknown etiology. Growing evidence indicates that immunological dysfunction is vital in the development of SCZ. Our study aims to uncover potential immune-linked hub genes and immune infiltration characteristics of SCZ, as well as to develop a diagnostic model based on immune-linked central genes. GSE38484 and GSE54913 chip expression data for patients with SCZ and healthy controls were retrieved. Weighted gene co-expression network analysis (WGCNA) was performed to identify major module genes and critical immune-linked genes. Functional enrichment analysis was conducted to elucidate the involvement of key genes in the immunological response to SCZ, along with the examination of their protein interactions. M

SUBMITTER: Lian K 

PROVIDER: S-EPMC10517044 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature