Telomere length and hTERT genetic variants as potential prognostic markers in multiple myeloma.

ABSTRACT: Telomere dysfunction is a notable event observed in many cancers contributing to their genomic instability. A major factor controlling telomere stability is the human telomerase reverse transcriptase catalytic subunit (hTERT). Telomere shortening has been observed in multiple myeloma (MM), a plasma cell malignancy with a complex and heterogeneous genetic background. In the present study, we aimed to analyse telomere length and hTERT genetic variants as potential markers of risk and survival in 251 MM patients. We found that telomere length was significantly shorter in MM patients than in healthy individuals, and patients with more advanced disease (stage III according to the International Staging System) had shorter telomeres than patients with less advanced disease. MM patients with hTERT

SUBMITTER: Dratwa M 

PROVIDER: S-EPMC10517131 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature