Pathway-specific polygenic scores for Alzheimer's disease are associated with changes in brain structure in younger and older adults.

ABSTRACT: Genome-wide association studies have identified multiple Alzheimer's disease risk loci with small effect sizes. Polygenic risk scores, which aggregate these variants, are associated with grey matter structural changes. However, genome-wide scores do not allow mechanistic interpretations. The present study explored associations between disease pathway-specific scores and grey matter structure in younger and older adults. Data from two separate population cohorts were used as follows: the Avon Longitudinal Study of Parents and Children, mean age 19.8, and UK Biobank, mean age 64.4 (combined n = 18 689). Alzheimer's polygenic risk scores were computed using the largest genome-wide association study of clinically assessed Alzheimer's to date. Relationships between subcortical volumes an

SUBMITTER: Harrison JR 

PROVIDER: S-EPMC10517196 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature