Uncovering therapeutic opportunities in the clinical development of antibody-drug conjugates.

ABSTRACT:

Introduction

Antibody-drug conjugates (ADCs) are a family of therapeutic agents that have demonstrated clinical activity in several indications.

Material and methods

In this article, we performed a deep analysis of their clinical landscape matched with public genomic human datasets from tumour antigen targets (TATs), to identify empty areas for clinical development.

Results

We observed that TATs used in haematological malignancies were more specific than the ones developed in solid cancers. Those included CD19, CD22, CD30, CD33 and CD79b. In solid tumours, we identified TATs, with approved ADCs, widely expressed in non-explored niche indications like Enfortumab vedotin (anti-Nectin4) in lung or cervical cancer; Tisotumab vedotin (anti-TF) in glioblastoma or pancreatic

SUBMITTER: Nieto-Jimenez C 

PROVIDER: S-EPMC10517221 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature