Dimensional clinical phenotyping using post-mortem brain donor medical records: post-mortem RDoC profiling is associated with Alzheimer's disease neuropathology.

ABSTRACT:

Introduction

Transdiagnostic dimensional phenotypes are essential to investigate the relationship between continuous symptom dimensions and pathological changes. This is a fundamental challenge to post-mortem work, as assessments of phenotypic concepts need to rely on existing records.

Methods

We adapted well-validated methodologies to compute National Institute of Mental Health Research Domain Criteria (RDoC) scores using natural language processing (NLP) from electronic health records (EHRs) obtained from post-mortem brain donors and tested whether cognitive domain scores were associated with Alzheimer's disease neuropathological measures.

Results

Our results confirm an association of EHR-derived cognitive scores with neuropathological findings. Notabl

SUBMITTER: Vogelgsang J 

PROVIDER: S-EPMC10517223 | biostudies-literature | 2023 Jul-Sep

REPOSITORIES: biostudies-literature