Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls.

ABSTRACT:

Background

Epidemiologic evidence suggests that environmental factors acting as endocrine disrupting chemicals (EDCs) are associated with mammographic breast density and the risk of breast cancer. Exposure to EDCs during puberty, a period of rapid breast development, may affect susceptibility to breast carcinogenesis.

Methods

In a cohort of 366 Chilean adolescents from the Growth and Obesity Cohort Study, we evaluated the relation between urinary concentrations of 15 suspected EDC biomarkers across three pubertal time points (Tanner breast stage 1 (B1), 4 (B4), and 1-year post-menarche) and breast fibroglandular volume (FGV; percent FGV [%FGV] and absolute FGV [aFGV]) and total breast volume (tBV) at 2-years post-menarche. We used linear mixed models to test differences in c

SUBMITTER: Yoon LS 

PROVIDER: S-EPMC10517447 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature