Small molecule targeting of the p38/Mk2 stress signaling pathways to improve cancer treatment.

ABSTRACT:

Purpose

Although a long-term goal of cancer therapy always has been the development of agents that selectively destroy cancer cells, more recent trends have been to seek secondary agents that sensitize cancer cells to existing treatment regimens. In this regard, the present study explored the possibility of using small molecule inhibitors of p38MAPK/MK2 stress signaling pathways as potential agents to enhance the sensitivity of cancer cells with abrogated G1 checkpoint to the DNA damaging agent etoposide by specifically targeting the DNA damage-induced G2 cell cycle checkpoint.

Methods

We have applied CCK8 and FACS-based viability assays and cell cycle analysis to investigate the effect of small molecules SB203580 and MK2.III on the sensitivity of small cell lung cancer cell

SUBMITTER: Alimbetov D 

PROVIDER: S-EPMC10517462 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature