Traumatic life events and risk for dementia: a systematic review and meta-analysis.

ABSTRACT:

Objectives

To systematically review the association between traumatic life events (TLE) and dementia risk.

Design

Systematic review and meta-analysis.

Data sources

APA, PsychINFO, Embase and MEDLINE from their inception to 29.05.21 and updated on 20.04.22.

Eligibility criteria for selecting studies

Original research articles published in peer reviewed journals examining the association between TLE and all cause dementia in individuals aged 60 and over. Two researchers independently assessed the risk of bias using the Newcastle-Ottawa Scale. We conducted a generic inverse variance random effects meta-analysis to provide an overall estimate of TLE impact on dementia risk.

Main outcome measures

Risk, odds and hazards ratios relating to dementia risk.

Res

SUBMITTER: Severs E 

PROVIDER: S-EPMC10517510 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature