Musculoskeletal manifestations associated with transthyretin-mediated (ATTR) amyloidosis: a systematic review.

ABSTRACT:

Background

Hereditary and wild-type transthyretin-mediated (ATTRv and ATTRwt) amyloidoses result from the misfolding of transthyretin and aggregation of amyloid plaques in multiple organ systems. Diagnosis of ATTR amyloidosis is often delayed due to its heterogenous and non-specific presentation. This review investigates the association of musculoskeletal (MSK) manifestations with ATTR amyloidosis and the delay from the onset of these manifestations to the diagnosis of ATTR amyloidosis.

Methods

This systematic review utilized Medline and EMBASE databases. Search criteria were outlined using a pre-specified patient, intervention, comparator, outcome, time, study (PICOTS) criteria and included: amyloidosis, ATTR, and MSK manifestations. Publication quality was assessed utilizi

SUBMITTER: Aldinc E 

PROVIDER: S-EPMC10517539 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature