Schistosoma japonicum EKLF/KLF1 is a potential immune target to tackle schistosomiasis.

ABSTRACT:

Background

Interruption of parasite reproduction by targeting migrating schistosomula is a promising strategy for managing schistosomiasis. Hepatic schistosomula proteins previously identified based on second-generation schistosome DNA sequencing were found to hold excellent potential for schistosomiasis japonica diagnosis and as vaccine candidates. However, there are still many unknown schistosomula proteins that warrant further investigations. Herein, a novel schistosomula protein, the Schistosoma japonicum erythroid Krüppel-like factor (SjEKLF/KLF1), was explored.

Methods

Sequence alignment was carried out to detect the amino acid sequence characteristics of SjEKLF. The expression profile of SjEKLF was determined by western blot and immunofluorescence analysis. Enzyme-lin

SUBMITTER: Piao X 

PROVIDER: S-EPMC10517563 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature