Morphine and Hydromorphone Effects, Side Effects, and Variability: A Crossover Study in Human Volunteers.

ABSTRACT:

Background

Balancing between opioid analgesia and respiratory depression continues to challenge clinicians in perioperative, emergency department, and other acute care settings. Morphine and hydromorphone are postoperative analgesic standards. Nevertheless, their comparative effects and side effects, timing, and respective variabilities remain poorly understood. This study tested the hypothesis that IV morphine and hydromorphone differ in onset, magnitude, duration, and variability of analgesic and ventilatory effects.

Methods

The authors conducted a randomized crossover study in healthy volunteers. Forty-two subjects received a 2-h IV infusion of hydromorphone (0.05 mg/kg) or morphine (0.2 mg/kg) 1 to 2 weeks apart. The authors measured arterial opioid concentrations, analg

SUBMITTER: Meissner K 

PROVIDER: S-EPMC10517626 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature