Deciphering pathological behavior of pediatric medullary thyroid cancer from single-cell perspective.

ABSTRACT:

Background

Pediatric medullary thyroid cancer (MTC) is one of the rare pediatric endocrine neoplasms. Derived from C cells of thyroid glands, MTC is more aggressive and more prompt to metastasis than other types of pediatric thyroid cancer. The mechanism remains unclear.

Methods

We performed single-cell transcriptome sequencing on the samples of the primary tumor and metastases lymph nodes from one patient diagnosed with MTC, and it is the first single-cell transcriptome sequencing data of pediatric MTC. In addition, whole exome sequencing was performed and peripheral blood was regarded as a normal reference. All cells that passed quality control were merged and analyzed in R to discover the association between tumor cells and their microenvironment as well as tumor pathogen

SUBMITTER: Chen DQ 

PROVIDER: S-EPMC10517655 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature