Ontology highlight
ABSTRACT:
SUBMITTER: Heil LR
PROVIDER: S-EPMC10517878 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Heil Lilian R LR Remes Philip M PM Canterbury Jesse D JD Yip Ping P Barshop William D WD Wu Christine C CC MacCoss Michael J MJ
Analytical chemistry 20230801 32
Data-independent acquisition (DIA) mass spectrometry has grown in popularity in recent years, because of the reproducibility and quantitative rigor of a systematic tandem mass spectrometry (MS/MS) sampling method. However, traditional DIA methods may spend valuable instrument time acquiring MS/MS spectra with no usable information in them, affecting sensitivity and quantitative performance. We developed a DIA strategy that dynamically adjusts the MS/MS windows during the chromatographic separati ...[more]