Early chest CT abnormalities to predict the subsequent occurrence of chronic lung allograft dysfunction.

ABSTRACT:

Introduction

Chronic lung allograft dysfunction (CLAD) can take two forms: bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS). The aim was to determine if chest-CT abnormalities after lung transplantation (LTx) could predict CLAD before respiratory functional deterioration.

Materials and methods

This monocentric retrospective study analyzed consecutive patients who underwent LTx from January 2015 to December 2018. Initial CT post-LTx (CTi) and a follow-up CT at least 9 months post-LTx (CTf) were reviewed. CLAD was defined as a persistent respiratory functional decline (> 20% of basal FEV₁) outside acute episode. A Cox regression was performed in univariate, then in multivariate analysis (including features with p < 0.01 in univariate o

SUBMITTER: Habert P 

PROVIDER: S-EPMC10517910 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature