Alpha synuclein modulates mitochondrial Ca²⁺ uptake from ER during cell stimulation and under stress conditions.

ABSTRACT: Alpha synuclein (a-syn) is an intrinsically disordered protein prevalent in neurons, and aggregated forms are associated with synucleinopathies including Parkinson's disease (PD). Despite the biomedical importance and extensive studies, the physiological role of a-syn and its participation in etiology of PD remain uncertain. We showed previously in model RBL cells that a-syn colocalizes with mitochondrial membranes, depending on formation of N-terminal helices and increasing with mitochondrial stress¹. We have now characterized this colocalization and functional correlates in RBL, HEK293, and N2a cells. We find that expression of a-syn enhances stimulated mitochondrial uptake of Ca²⁺ from the ER, depending on formation of its N-terminal helices but not on its disorder

SUBMITTER: Ramezani M 

PROVIDER: S-EPMC10518018 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature