Esophageal Epithelium and Lamina Propria Are Unevenly Involved in Eosinophilic Esophagitis.

ABSTRACT:

Background & aims

The nature of the involvement of esophageal tissue in eosinophilic esophagitis (EoE) is unclear. We estimated the intrabiopsy site agreements of the EoE Histologic Scoring System (EoEHSS) scores for the grade (degree) and stage (extent) of involvement of the esophageal epithelial and lamina propria and examined if the EoE activity status influenced the intrabiopsy site agreement.

Methods

Demographic, clinical, and EoEHSS scores collected as part of the prospective Outcome Measures for Eosinophilic Gastrointestinal Diseases Across Ages study were analyzed. A weighted Cohen's kappa agreement coefficient (k) was used to calculate the pairwise agreements for proximal:distal, proximal:middle, and middle:distal esophageal biopsy sites, separately for grade and st

SUBMITTER: Hiremath G 

PROVIDER: S-EPMC10518022 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature