Antibiotic Exposure is Associated With a Risk of Esophageal Adenocarcinoma.

ABSTRACT:

Background & aims

Antibiotic exposure leads to changes in the gut microbiota. Our objective was to evaluate the association between antibiotic exposure and esophageal adenocarcinoma (EAC) risk.

Methods

We performed a nested case-control study using data from the Veterans Health Administration from 2004 through 2020. The case group consisted of patients who received an incident diagnosis of EAC. For each case, up to 20 matched controls were selected using incidence density sampling. Our primary exposure of interest was any oral or intravenous antibiotic use. Our secondary exposures included cumulative number of days of exposure and classification of antibiotics by various subgroups. Conditional logistic regression was used to estimate the crude and adjusted odds ratios (aORs)

SUBMITTER: Thanawala SU 

PROVIDER: S-EPMC10518027 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature