Specificity of cancer-related chromosomal translocations is linked to proximity after the DNA double-strand break and subsequent selection.

ABSTRACT: Most cancer-related chromosomal translocations appear to be cell type specific. It is currently unknown why different chromosomal translocations occur in different cells. This can be due to either the occurrence of particular translocations in specific cell types or adaptive survival advantage conferred by translocations only in specific cells. We experimentally addressed this question by double-strand break (DSB) induction at MYC, IGH, AML and ETO loci in the same cell to generate chromosomal translocations in different cell lineages. Our results show that any translocation can potentially arise in any cell type. We have analyzed different factors that could affect the frequency of the translocations, and only the spatial proximity between gene loci after the D

SUBMITTER: Canoy RJ 

PROVIDER: S-EPMC10518054 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature