Synergistic effect of YOD1 and USP21 on the Hippo signaling pathway.

ABSTRACT:

Background

Deubiquitinating enzymes (DUBs) comprise a family of proteases responsible for cleaving the peptide or isopeptide bond between ubiquitin and its substrate proteins. Ubiquitin is essential for regulating diverse cellular functions by attaching to target proteins. The Hippo signaling pathway plays a crucial role in controlling tissue size, cell proliferation, and apoptosis. In a previous study, we discovered that YOD1 regulates the Hippo signaling pathway by deubiquitinating the neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4), an E3 ligase of large tumor suppressor kinase 1 (LATS1). Here, our aim was to investigate potential substrates of YOD1 implicated in the Hippo signaling pathway.

Methods

We employed various bioinformatics tools

SUBMITTER: Park SS 

PROVIDER: S-EPMC10518088 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature