Urinary peptides provide information about the risk of mortality across a spectrum of diseases and scenarios.

ABSTRACT:

Background

There is evidence of pre-established vulnerability in individuals that increases the risk of their progression to severe disease or death, although the mechanisms causing this are still not fully understood. Previous research has demonstrated that a urinary peptide classifier (COV50) predicts disease progression and death from SARS-CoV-2 at an early stage, indicating that the outcome prediction may be partly due to vulnerabilities that are already present. The aim of this study is to examine the ability of COV50 to predict future non-COVID-19-related mortality, and evaluate whether the pre-established vulnerability can be generic and explained on a molecular level by urinary peptides.

Methods

Urinary proteomic data from 9193 patients (1719 patients sampled at inte

SUBMITTER: Keller F 

PROVIDER: S-EPMC10518109 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature