Inflammation-inducible promoters to overexpress immune inhibitory factors by MSCs.

ABSTRACT:

Background

Mesenchymal stromal cells (MSCs) are excessively investigated in the context of inflammation-driven diseases, but the clinical results are often moderate. MSCs are naturally activated by inflammatory signals, which lead to the secretion of immune inhibitory factors in inflamed tissues. Many work groups try to improve the therapeutic outcome of MSCs by genetic modification and the constitutive overexpression of immune modulatory transgenes. However, the ectopic secretion of immune inhibitory transgenes increases the chances of infections, and constitutive transgene expression is not necessary for chronic diseases undergoing different inflammatory stages.

Methods

We designed and tested inflammation-induced promoters to control transgene expression from integrating l

SUBMITTER: Selich A 

PROVIDER: S-EPMC10518110 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature