Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment.

ABSTRACT:

Background

Gestational exposure to polychlorinated biphenyls (PCBs) has been associated with elevated risk for neurodevelopmental disorders. Placental epigenetics may serve as a potential mechanism of risk or marker of altered placental function. Prior studies have associated differential placental DNA methylation with maternal PCB exposure or with increased risk of autism spectrum disorder (ASD). However, sequencing-based placental methylomes have not previously been tested for simultaneous associations with maternal PCB levels and child neurodevelopmental outcomes.

Objectives

We aimed to identify placental DNA methylation patterns associated with maternal PCB levels and child neurodevelopmental outcomes in the high-risk ASD MARBLES cohort.

Methods

We measured 209 PC

SUBMITTER: Mouat JS 

PROVIDER: S-EPMC10518186 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature