Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes.

ABSTRACT: Better understanding of the early events in the development of type 1 diabetes is needed to improve prediction and monitoring of the disease progression during the substantially heterogeneous presymptomatic period of the beta cell damaging process. To address this concern, we used mass spectrometry-based proteomics to analyse longitudinal pre-onset plasma sample series from children positive for multiple islet autoantibodies who had rapidly progressed to type 1 diabetes before 4 years of age (n = 10) and compared these with similar measurements from matched children who were either positive for a single autoantibody (n = 10) or autoantibody negative (n = 10). Following statistical analysis of the longitudinal data, targeted serum proteomics was used to verify 11 proteins putatively associa

SUBMITTER: Hirvonen MK 

PROVIDER: S-EPMC10518308 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature