Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosus.

ABSTRACT:

Background

Patients with systemic lupus erythematosus (SLE) exhibit a high risk for cardiovascular diseases (CVD) which is not fully explained by the classical Framingham risk factors. SLE is characterized by major metabolic alterations which can contribute to the elevated prevalence of CVD.

Methods

A comprehensive analysis of the circulating metabolome and lipidome was conducted in a large cohort of 211 women with SLE who underwent a multi-detector computed tomography scan for quantification of coronary artery calcium (CAC), a robust predictor of coronary heart disease (CHD).

Findings

Beyond traditional risk factors, including age and hypertension, disease activity and duration were independent risk factors for developing CAC in women with SLE. The presence of corona

SUBMITTER: Urbain F 

PROVIDER: S-EPMC10518349 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature