Ca²⁺ ions facilitate the organization of the Annexin A2/S100A10 heterotetramer.

ABSTRACT: Annexin A2 (A2) is a member of the Annexin family, which contains Ca²⁺ -regulated phospholipid-binding proteins. Annexins associate with S100 proteins to form heterotetramers. The A2/S100A10 heterotetramer (A2t) is the most extensively studied of these heterotetramers. It induces membrane microdomain formation, causes membrane budding, and facilitates proliferation of some cancers. In this work, the first molecular dynamics (MD) study on the complete A2t of 868 amino acids was performed. MD trajectories of more than 600 ns each were generated for complete A2t complexes with and without Ca²⁺ ions. The outward extension of membrane-binding residues A2-K279 and A2-K281 was shown to be inhibited in the absence of Ca²⁺ as they were captured by Ca²⁺ -b

SUBMITTER: Lindsay S 

PROVIDER: S-EPMC10518368 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature