Brain response in heavy drinkers during cross-commodity alcohol and money discounting with potentially real rewards: A preliminary study.

ABSTRACT:

Background

Alcohol use disorder (AUD) is associated with exaggerated preference for immediate rewards, a candidate endophenotype for use disorders. Addiction symptomology is often well-described by the preference for immediate intoxication over other delayed prosocial rewards. We measured brain activation in AUD-implicated regions during a cross-commodity delay discounting (CCD) task with choices for immediate alcohol and delayed money.

Methods

Heavy drinkers (n=24) experienced a brief intravenous alcohol infusion prime, regained sobriety, then chose between 'One Shot' and delayed money in an adjusting delay CCD task (sober and intoxicated); also during fMRI (sober). Participants also performed a behavioral sensation seeking task and completed self-report inventories

SUBMITTER: Lungwitz EA 

PROVIDER: S-EPMC10518510 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature