Dataset Information

Early Omicron infection is associated with increased reinfection risk in older adults in long-term care and retirement facilities.

ABSTRACT:

Background

Older adults are at increased risk of SARS-CoV-2 Omicron infection and severe disease, especially those in congregate living settings, despite high SARS-CoV-2 vaccine coverage. It is unclear whether hybrid immunity (combined vaccination and infection) after one Omicron infection provides increased protection against subsequent Omicron reinfection in older adults.

Methods

Incidence of SARS-CoV-2 Omicron infection was examined in 750 vaccinated residents of long-term care and retirement homes in the observational cohort COVID in Long-Term Care Study in Ontario, Canada, within a 75-day period (July to September 2022). Risk of infection was assessed by Cox proportional hazards regression. Serum anti-spike and anti-RBD SARS-CoV-2 IgG and IgA antibodies, microneutralization titres, and spike-specific T cell memory responses, were examined in a subset of 318 residents within the preceding three months.

Findings

133 of 750 participants (17.7%) had a PCR-confirmed Omicron infection during the observation period. Increased infection risk was associated with prior Omicron infection (at 9-29 days: 47.67 [23.73-95.76]), and this was not attributed to days since fourth vaccination (1.00 [1.00-1.01]) or residence outbreaks (>6 compared to ≤6: 0.95 [0.37-2.41]). Instead, reinfected participants had lower serum neutralizing antibodies to ancestral and Omicron BA.1 SARS-CoV-2, and lower anti-RBD IgG and IgA antibodies, after their initial Omicron infection.

Interpretation

Counterintuitively, SARS-CoV-2 Omicron infection was associated with increased risk of Omicron reinfection in residents of long-term care and retirement homes. Less robust humoral hybrid immune responses in older adults may contribute to risk of Omicron reinfection.

Funding

COVID-19 Immunity Task Force of the Public Health Agency of Canada.

SUBMITTER: Breznik JA

PROVIDER: S-EPMC10518514 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Early Omicron infection is associated with increased reinfection risk in older adults in long-term care and retirement facilities.

Breznik Jessica A JA Rahim Ahmad A Zhang Ali A Ang Jann J Stacey Hannah D HD Bhakta Hina H Clare Rumi R Liu Li-Min LM Kennedy Allison A Hagerman Megan M Kajaks Tara T Miller Matthew S MS Nazy Ishac I Bramson Jonathan L JL Costa Andrew P AP Bowdish Dawn M E DME

EClinicalMedicine 20230821

<h4>Background</h4>Older adults are at increased risk of SARS-CoV-2 Omicron infection and severe disease, especially those in congregate living settings, despite high SARS-CoV-2 vaccine coverage. It is unclear whether hybrid immunity (combined vaccination and infection) after one Omicron infection provides increased protection against subsequent Omicron reinfection in older adults.<h4>Methods</h4>Incidence of SARS-CoV-2 Omicron infection was examined in 750 vaccinated residents of long-term care ...[more]

PMID: 37753447

Similar Datasets

Project description:BackgroundResistance training and other forms of physical exercise are commonly suggested to promote brain health, yet the relationship between resistance training and brain structure in aging is poorly understood. We examined the short- and long-term influence of one year of supervised resistance training at two different loadings on brain structure in aging.MethodsIn the LISA (LIve active Successful Ageing) study, well-functioning older adults at retirement age (mean age: 66 ± 2 years) were randomized to one year of heavy resistance training (HRT), moderate intensity training (MIT), or a non-exercising control group (CON). Magnetic resonance imaging (MRI) of the brain was performed at baseline, 1-, 2-, and 4-years follow ups. Trajectories of total grey matter, hippocampus, dorsolateral prefrontal cortex (dlPFC), ventrolateral prefrontal cortex (vlPFC), and white matter hyperintensities were analyzed in relation to changes in muscle strength.ResultsIndividuals (n = 276) with MRI scans at all 4 timepoints were included (HRT, n = 96; MIT, n = 95; CON, n = 85). Total grey matter volume decreased with time across all groups (F3,819 = 231.549, p < 0.001, η 2 = 0.46), as did hippocampal (F3,819 = 310.07, p < 0.001, η 2 = 0.53), vlPFC (F3,818 = 74.380, p < 0.001, η 2 = 0.21), and dlPFC (F3,818 = 3.640, p = 0.013, η 2 = 0.01) volumes. White matter hyperintensity volumes increased (F3,819 = 101.876, p < 0.001, η 2 = 0.27). There were no significant group x time interactions for any of the brain structures. Additional cortical and subcortical vertex-wise analyses showed no group differences. Change in isometric leg strength was weakly associated with change in white matter hyperintensity volume across all individuals (r2 = 0.01, p = 0.048).ConclusionsOne year of resistance training in well-functioning older adults at retirement age did not influence volume changes in selected brain regions over a 4-year period.Trial registrationThe study was approved by the regional ethics committee and registered on clinicaltrials.gov 2014-04-24 (NCT02123641).

Dataset Information

Early Omicron infection is associated with increased reinfection risk in older adults in long-term care and retirement facilities.

Background

Methods

Findings

Interpretation

Funding

Publications

Early Omicron infection is associated with increased reinfection risk in older adults in long-term care and retirement facilities.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets