Reduced PDE4D7 in prostate cancer correlates with genomic downregulation within the upstream PDE4D coding region.

ABSTRACT:

Aim

PDE4D7 expression is significantly associated with prostate cancer (PCa) progression, representing an attractive prognostic biomarker. We sought to determine whether other genes in the PDE4D coding region were associated.

Patients & methods

RNA from biopsy punch samples of resected tumor tissue was analyzed via RNA sequencing. RT-qPCR was used to determine PDE4D7 score.

Results

Numerous genomic sequences within the PDE4D coding region on Chr5q12 revealed similar mRNA expression profiles to PDE4D7. PART1 had a significantly similar expression pattern to PDE4D7 across samples, correlating with disease progression. However, many other genes also exhibited matched expression to PDE4D7, including miRNAs and lncRNA

SUBMITTER: Gulliver C 

PROVIDER: S-EPMC10518809 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature