Galectin-3 and HFpEF: Clarifying an Emerging Relationship.

ABSTRACT:

Introduction

HFpEF is one of the leading causes of death whose burden is estimated to expand in the coming decades. This paper examines the relationship between circulating levels of galectin-3, an emerging risk factor for cardiovascular disease, and the clinical diagnosis of HFpEF.

Methods

The authors reviewed peer-reviewed literature and 18 studies met the inclusion criteria. Study characteristics, study outcome definitions, assay characteristics, main findings, and measures of association were tabulated and summarized.

Results

Five studies found significant associations between galectin-3 and HFpEF diagnosis compared to healthy controls, and one did not. Five studies found significant associations between galectin- 3 concentration in circulation and severity of dia

SUBMITTER: Baccouche BM 

PROVIDER: S-EPMC10518880 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature