Computed tomography reveals hypertrophic remodelling of the diaphragm in cystic fibrosis but not in COPD.

ABSTRACT:

Background

Computed tomography (CT) is increasingly used for assessing skeletal muscle characteristics. In cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD), reduced limb muscle mass predicts poor clinical outcomes. However, the degree to which quantity or quality of respiratory and nonrespiratory muscles is affected by these diseases remains controversial.

Methods

Thoracic CT images of 29 CF, 21 COPD and 20 normal spirometry control subjects were analysed to measure indices of muscle quantity (volume or cross-sectional area) and quality (radiodensity) in respiratory (diaphragm, abdominal) and nonrespiratory (pectoralis, lumbar paraspinal) muscles. Multivariable linear regression assessed relationships of CT measurements with body mass index (BMI), forced

SUBMITTER: Ostadan F 

PROVIDER: S-EPMC10518894 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature