Prognosis of Midkine and AT1R expression in resectable head and neck squamous cell carcinoma.

ABSTRACT:

Background

Research studies have demonstrated that Midkine (MDK) can influence the expression and activity of Renin-angiotensin system (RAS) components. Angiotensin II is involved in tumor growth and angiogenesis in different cancers. We previously observed Angiotensin II receptor blockers (ARBs) improve the survival rates of patients with oral cancers. These findings have prompted us to investigate whether MDK can influence the RAS pathway, mainly through its association with angiotensin II type 1 receptor (AT1R), which contributes to the observed poor prognosis in head and neck squamous cell carcinoma (HNSCC) patients.

Methods

MDK and AT1R expressions were examined in 150 HNSCC patients post-operation by immunohistochemical staining between 1 January 2010 and 31 December 2

SUBMITTER: Chiu TJ 

PROVIDER: S-EPMC10518915 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature