Meta-analysis reveals the vaginal microbiome is a better predictor of earlier than later preterm birth.

ABSTRACT:

Background

High-throughput sequencing measurements of the vaginal microbiome have yielded intriguing potential relationships between the vaginal microbiome and preterm birth (PTB; live birth prior to 37 weeks of gestation). However, results across studies have been inconsistent.

Results

Here, we perform an integrated analysis of previously published datasets from 12 cohorts of pregnant women whose vaginal microbiomes were measured by 16S rRNA gene sequencing. Of 2039 women included in our analysis, 586 went on to deliver prematurely. Substantial variation between these datasets existed in their definition of preterm birth, characteristics of the study populations, and sequencing methodology. Nevertheless, a small group of taxa comprised a vast majority of the measured microb

SUBMITTER: Huang C 

PROVIDER: S-EPMC10518966 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature