Intrathecal dexmedetomidine as an adjuvant to plain ropivacaine for spinal anesthesia during cesarean section: a prospective, double-blinded, randomized trial for ED₅₀ determination using an up-down sequential allocation method.

ABSTRACT:

Background

Intrathecal dexmedetomidine, as an adjuvant to local anesthetics, has been reported to improve the quality of spinal anesthesia and reduce the required local anesthetic dose. However, the optimal dosage regimen for intrathecal dexmedetomidine combined with plain ropivacaine for cesarean section (CS) remains undetermined. The present study aimed to determine the median effective dose (ED₅₀) of intrathecal dexmedetomidine as an adjuvant to plain ropivacaine for spinal anesthesia during CS.

Methods

Sixty parturients undergoing CS were randomly assigned to either group: plain ropivacaine 8 mg (Group Rop₈) or plain ropivacaine 10 mg (Group Rop₁₀). The initial dosage of intrathecal dexmedetomidine in each group was 5 µg. The effective do

SUBMITTER: Mo X 

PROVIDER: S-EPMC10519004 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature