The PTX3/TLR4 autocrine loop as a novel therapeutic target in triple negative breast cancer.

ABSTRACT:

Background

The pattern recognition receptor long pentraxin-3 (PTX3) plays conflicting roles in cancer by acting as an oncosuppressor or as a pro-tumor mediator depending on tumor context. Triple negative breast cancer (TNBC) represents the most aggressive histotype of breast cancer, characterized by the lack of efficacious therapeutic targets/approaches and poor prognosis. Thus, the characterization of new molecular pathways and/or alternative druggable targets is of great interest in TNBC.

Methods

The expression of PTX3 in BC tumor samples and in BC cell lines has been analyzed using the Gene Expression-Based Outcome for Breast Cancer Online (GOBO), qPCR, Western blot and ELISA assay. The contribution of tumor and stromal cells to PTX3 production in TNBC was assessed by ana

SUBMITTER: Giacomini A 

PROVIDER: S-EPMC10519006 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature