Natural killer cells and their exosomes in viral infections and related therapeutic approaches: where are we?

ABSTRACT: Innate immunity is the first line of the host immune system to fight against infections. Natural killer cells are the innate immunity lymphocytes responsible for fighting against virus-infected and cancerous cells. They have various mechanisms to suppress viral infections. On the other hand, viruses have evolved to utilize different ways to evade NK cell-mediated responses. Viruses can balance the response by regulating the cytokine release pattern and changing the proportion of activating and inhibitory receptors on the surface of NK cells. Exosomes are a subtype of extracellular vesicles that are involved in intercellular communication. Most cell populations can release these nano-sized vesicles, and it was shown that these vesicles produce identical outcomes to the originating cell from

SUBMITTER: Razizadeh MH 

PROVIDER: S-EPMC10519079 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature