Integrative rare disease biomedical profile based network supporting drug repurposing or repositioning, a case study of glioblastoma.

ABSTRACT:

Background

Glioblastoma (GBM) is the most aggressive and common malignant primary brain tumor; however, treatment remains a significant challenge. This study aims to identify drug repurposing or repositioning candidates for GBM by developing an integrative rare disease profile network containing heterogeneous types of biomedical data.

Methods

We developed a Glioblastoma-based Biomedical Profile Network (GBPN) by extracting and integrating biomedical information pertinent to GBM-related diseases from the NCATS GARD Knowledge Graph (NGKG). We further clustered the GBPN based on modularity classes which resulted in multiple focused subgraphs, named mc_GBPN. We then identified high-influence nodes by performing network analysis over the mc_GBPN and validated those nodes that cou

SUBMITTER: McGowan E 

PROVIDER: S-EPMC10519087 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature