Rational design of poly(peptide-ester) block copolymers for enzyme-specific surface resorption.

ABSTRACT: Tissue resorption and remodeling are pivotal steps in successful healing and regeneration, and it is important to design biomaterials that are responsive to regenerative processes in native tissue. The cell types responsible for remodeling, such as macrophages in the soft tissue wound environment and osteoclasts in the bone environment, utilize a class of enzymes called proteases to degrade the organic matrix. Many hydrophobic thermoplastics used in tissue regeneration are designed to degrade and resorb passively through hydrolytic mechanisms, leaving the potential of proteolytic-guided degradation underutilized. Here, we report the design and synthesis of a tyrosol-derived peptide-polyester block copolymer where protease-mediated resorption is tuned through changing the chemistry of the b

SUBMITTER: Fung SL 

PROVIDER: S-EPMC10519181 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature