Urine proteomic analysis of the rat e-cigarette model.

ABSTRACT:

Background

We were curious if the urinary proteome could reflect the effects of e-cigarettes on the organism.

Methods

Urine samples were collected from a rat e-cigarette model before, during, and after two weeks of e-cigarette smoking. Urine proteomes before and after smoking of each rat were compared individually, while the control group was set up to rule out differences caused by rat growth and development.

Results

Fetuin-B, a biomarker of chronic obstructive pulmonary disease (COPD), and annexin A2, which is recognized as a multiple tumour marker, were identified as differential proteins in five out of six smoking rats on day 3. To our surprise, odourant-binding proteins expressed in the olfactory epithelium were also found and were significantly upregulated. Path

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10519197 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature