Prenatal exposure to polycyclic aromatic hydrocarbons and cognition in early childhood.

ABSTRACT:

Background

Epidemiological evidence for gestational polycyclic aromatic hydrocarbon (PAH) exposure and adverse child cognitive outcomes is mixed; little is known about critical windows of exposure.

Objective

We investigated associations between prenatal PAH exposure and child cognition in a large, multi-site study.

Methods

We included mother-child dyads from two pooled prospective pregnancy cohorts (CANDLE and TIDES, N = 1,223) in the ECHO-PATHWAYS Consortium. Seven urinary mono-hydroxylated PAH metabolites were measured in mid-pregnancy in both cohorts as well as early and late pregnancy in TIDES. Child intelligence quotient (IQ) was assessed between ages 4-6. Associations between individual PAH metabolites and IQ were estimated with multivariable linear regression.

SUBMITTER: Sun B 

PROVIDER: S-EPMC10519343 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature