Association of vitamin D receptor gene polymorphism with the risk of sepsis: A systematic review and meta-analysis.

ABSTRACT:

Background

To investigate the association between sepsis and the vitamin D receptor (VDR) gene polymorphisms.

Methods

Databases including PubMed, Cochrane Library, EMbase, CNKI, Wanfang Data, and VIP Data were systematically searched. The association was assessed using odds ratios (ORs), and 95% confidence intervals (CIs). The statistical tests were performed using Review Manager 5.4.

Results

We identified a total of 5 studies. The relationship between VDR gene polymorphisms (Apa I, Bsm I, Taq I, and Fok I), and incidence of sepsis was investigated. The results of this meta-analysis showed that the allelic contrast model (F vs f, P = .03, OR = 0.65, 95% CI = 0.44-0.95), dominant genetic model (FF vs Ff + ff, P = .02, OR = 0.53, 95% CI = 0.30-0.91), and codominance gen

SUBMITTER: Li Q 

PROVIDER: S-EPMC10519506 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature