Identification of immune microenvironment changes, immune-related pathways and genes in male androgenetic alopecia.

ABSTRACT:

Background

Although androgenetic alopecia (AGA) is classified as a non-inflammatory alopecia, histological evidence of microinflammation has long been recognized. However, changes in the immune microenvironment, immune-related pathways and the expression of immune-related genes (IRGs) involved in AGA remain unclear.

Methods

The microarray gene expression data (GSE36169) from patients with male AGA were analyzed. gene set enrichment analysis (GSEA) among statistically changed genes was done. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses among differentially expressed genes were performed. differentially expressed genes were screened to identify IRGs based on the ImmPort database. The cytohubba-MCC plugin of Cytoscape was applied to screen hub immune genes

SUBMITTER: Xiong HD 

PROVIDER: S-EPMC10519577 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature